Table 1.
Patient characteristics overall and according to muscle density
| Characteristic | All n = 403 | Myosteatosis n = 150 (37.2) | Normal Musculature n = 253 (62.8) | p |
|---|---|---|---|---|
| Age (years) | 60.9 (10.3) | 65.2 (10.9) | 58.4 (9.0) | < 0.0001 |
| Sex | < 0.0001 | |||
| Male | 329 (81.6) | 97 (64.7) | 232 (91.7) | |
| Female | 74 (18.4) | 53 (35.3) | 21 (8.3) | |
| Race | 0.14 | |||
| White | 361 (89.6) | 130 (86.7) | 231 (91.3) | |
| BIPOC | 42 (10.4) | 20 (13.3) | 22 (8.7) | |
| BMI (kg/m2) | 27.8 (5.8) | 25.3 (6.1) | 29.3 (5.1) | < 0.0001 |
| SMI (cm2/m2) | 53.1 (11.7) | 44.3 (8.4) | 58.3 (10.1) | < 0.0001 |
| VAT (cm2) | 163.3 (96.3) | 129.6 (88.1) | 183.3 (95.5) | < 0.0001 |
| SAT (cm2) | 181.4 (94.7) | 165.7 (102.9) | 190.7 (88.5) | 0.01 |
| IMAT (cm2) | 13.0 (8.1) | 16.4 (9.3) | 11.0 (6.5) | < 0.0001 |
| TAT (cm2) | 357.7 (164.5) | 311.8 (168.0) | 385.0 (156.4) | < 0.0001 |
| SMD (HU) | 38.6 (8.3) | 30.5 (5.8) | 43.4 (5.3) | < 0.0001 |
| Low Muscle Mass | < 0.0001 | |||
| Yes | 135 (33.5) | 85 (56.7) | 50 (19.8) | |
| No | 268 (66.5) | 65 (43.3) | 203 (80.2) | |
| Comorbidities | 2.2 (1.8) | 2.3 (1.8) | 2.1 (1.9) | 0.33 |
| Tumor site | 0.001 | |||
| Oropharynx | 206 (51.1) | 61 (40.7) | 145 (57.3) | |
| Larynx | 100 (24.8) | 51 (34.0) | 49 (19.4) | |
| Other | 32 (7.9 | 38 (25.3) | 59 (23.3) | |
| AJCC stage | 0.005 | |||
| 0-II | 137 (34.0) | 39 (26.0) | 98 (38.7) | |
| III | 100 (24.8) | 40 (26.7) | 60 (23.7) | |
| IV | 166 (41.2)_ | 71 (47.3) | 95 (37.6) | |
| HPV | < 0.0001 | |||
| Positive | 164 (40.7) | 40 (26.7) | 124 (49.0) | |
| Negative | 96 (23.8) | 48 (32.0) | 48 (19.0) | |
| Inapplicable | 143 (35.5) | 62 (41.3) | 81 (32.0) | |
| Treatment | 0.001 | |||
| RT only | 27 (6.7) | 18 (12.0) | 9 (3.6) | |
| RT + Chemotherapy | 376 (93.3) | 132 (88.0) | 244 (96.4) | |
| Smoking status | 0.02 | |||
| Current | 110 (27.3) | 50 (33.3) | 60 (23.7) | |
| Former | 202 (50.1) | 76 (50.7) | 126 (49.8) | |
| Never | 91 (22.6) | 24 (16.0) | 67 (26.5) | |
| Alcohol consumption | 0.41 | |||
| Current | 228 (56.6) | 81 (54.0) | 147 (58.1) | |
| Former | 88 (21.8) | 37 (24.7) | 51 (20.2) | |
| Never | 69 (17.1) | 23 (15.3) | 46 (18.2) | |
| Unknown | 18 (4.5) | 9 (6.0) | 9 (3.6) | |
| Unplanned hospitalizations | 0.12 | |||
| None | 308 (76.4) | 121 (80.7) | 187 (73.9) | |
| One | 95 (23.6) | 29 (19.3) | 66 (26.1) |
Abbreviations: AJCC American Joint Committee on Cancer, AMS Altered mental status, BMI Body mass index, HNC Head and neck cancer, HU Hounsfield Units, HPV Human papilloma virus, IMAT Intermuscular adipose tissue, kg kilograms, SAT Subcutaneous adipose tissue, SMD Skeletal muscle density, SMI Skeletal muscle index, TAT Total adipose tissue, VAT Visceral adipose tissue
Data are presented as frequency (percent), mean (SD), or median (IQR)