Table 1.
Longevity of different C. elegans strains upon C. neoformans 32045 and C. gattii 56992 infections
| Strain | Mean | SD | SE | Median | Max | No. | P-value | % | ||
|---|---|---|---|---|---|---|---|---|---|---|
| + E. coli OP50 | 9.15 | 1.75 | 0.15 | 9.00 | 12.00 | 141 | ||||
| Wild-type | + C. neoformans | 3.04 | 1.57 | 0.13 | 3.00 | 9.00 | 138 | < 0.0001 | **** | -66.78% |
| + C. gattii### | 4.10 | 1.73 | 0.15 | 4.00 | 9.00 | 139 | < 0.0001 | **** | -55.19% | |
| + E. coli OP50 | 5.79 | 1.99 | 0.17 | 6.00 | 9.00 | 143 | ||||
| sek-1 | + C. neoformans | 2.63 | 1.21 | 0.11 | 2.50 | 6.00 | 138 | < 0.0001 | **** | -54.58% |
| + C. gattiins | 2.36 | 1.12 | 0.10 | 2.00 | 5.00 | 139 | < 0.0001 | **** | -59.24% | |
| + E. coli OP50 | 16.89 | 6.90 | 0.59 | 21.00 | 27.00 | 138 | ||||
| age-1 | + C. neoformans | 5.50 | 1.78 | 0.15 | 6.00 | 10.00 | 141 | < 0.0001 | **** | -67.44% |
| + C. gattii# | 6.80 | 2.21 | 0.19 | 7.00 | 11.00 | 139 | < 0.0001 | **** | -59.74% | |
| + E. coli OP50 | 3.97 | 1.76 | 0.15 | 4.00 | 7.00 | 144 | ||||
| daf-16 | + C. neoformans | 1.62 | 1.06 | 0.09 | 1.00 | 5.00 | 138 | < 0.0001 | **** | -59.19% |
| + C. gattiins | 1.51 | 0.95 | 0.08 | 1.00 | 5.00 | 136 | < 0.0001 | **** | -61.96% | |
| + E. coli OP50 | 7.64 | 2.33 | 0.20 | 8.00 | 11.00 | 137 | ||||
| jnk-1 | + C. neoformans | 2.64 | 1.39 | 0.12 | 3.00 | 6.00 | 139 | < 0.0001 | **** | -65.45% |
| + C. gattiins | 2.50 | 1.38 | 0.12 | 3.00 | 6.00 | 141 | < 0.0001 | **** | -67.28% | |
| + E. coli OP50 | 6.85 | 1.93 | 0.17 | 7.00 | 10.00 | 137 | ||||
| sir-2.1 | + C. neoformans | 2.71 | 1.16 | 0.10 | 3.00 | 5.00 | 139 | < 0.0001 | **** | -60.44% |
| + C. gattiins | 2.53 | 1.18 | 0.10 | 3.00 | 5.00 | 140 | < 0.0001 | **** | -63.07% | |
| + E. coli OP50 | 5.57 | 1.71 | 0.14 | 6.00 | 8.00 | 140 | ||||
| osr-1 | + C. neoformans | 2.77 | 1.28 | 0.11 | 3.00 | 5.00 | 136 | < 0.0001 | **** | -50.27% |
| + C. gattiins | 2.66 | 1.34 | 0.11 | 3.00 | 5.00 | 138 | < 0.0001 | **** | -52.24% | |
Note: Means, standard deviation (SD), standard error (SE), median, and maximum of lifespan were shown in days. Total worms (No.) were represented as summation of worms in triplicates (with censored worms excluded). The lifespan data were analyzed using the log‐rank test and P‐values for each individual experiment were shown when compared to corresponding control as *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; NS, not significant (P > 0.05). Comparison of statistically significant differences between C. neoformans and C. gattii infected groups was indicated as #P < 0.05; ##P < 0.01; ###P < 0.001; ####P < 0.0001; NS, not significant (P > 0.05). Results presented in Fig. 1B-H