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. 2022 Jun 21;22:685. doi: 10.1186/s12885-022-09711-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — GSTM5 expression and its DNA methylation status in LUAD. A Heat map of GSTM5 expression and DNA methylation status. B Plots chart comparing the GSTM5 methylation level in LUAD and normal tissues. C Comparison of the average methylation level of GSTM5 gene between LUAD and matched normal tissues. D Correlation analyses between CpG sites methylation frequencies and GSTM5 expression. E The correlation between GSTM5 expression and the average DNA methylation in LUAD