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. 2022 Jun 21;22:685. doi: 10.1186/s12885-022-09711-0

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — 5-Aza-CdR demethylated the GSTM5 promoter region and promoted GSTM5 expression in LUAD cells. A The CpG island of GSTM5 was predicted by MethPrimer. B Methylation status of the promoter region of GSTM5 in lung cancer cells. C Effect of 5-Aza-CdR on GSTM5 demethylation in LUAD cells. D GSTM5 mRNA expression analysis by RT-PCR in LUAD cells following 5-Aza-CdR treatment for 48 h. Full length gels and blots are also included in additional file 4. M: amplification product of methylated primers; U: amplification product with non-methylated primers. ^*P < 0.05