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. 2022 Jun 22;20:214. doi: 10.1186/s12916-022-02404-2

Table 4.

Summary of colocalization results in 13 genomic risk loci

Chromosome loci LBD-AD LBD-PD
PP3 PP4 Best Causal PP3 PP4 Best causal
1q22 0.0064 0.0370 rs35603727b 0.0105 0.9893 rs35603727b
2q14.3 0.0002 0.9998a rs4663105 0.0198 0.1529 rs4663105
4p16.3 0.0213 0.4839 rs34311866b 0.0023 0.9976a rs34311866b
4q22.1 0.0432 0.5154 rs7680557 1.0000a 0.0000 rs356203
5q12.1 0.0001 0.0012 rs4647170 0.0212 0.3983 rs75646569
5q33.3 0.0023 0.1630 rs6555853 0.0002 0.0168 rs9790947b
6p21.1 0.0014 0.2463 rs34346157 0.0002 0.0602 rs13216201b
8p21.1 0.0009 0.8264a rs1532278b 0.0000 0.0400 rs1532276
10p14 0.0012 0.4398 rs7920721 0.0000 0.0021 rs11257240b
11q12.2 0.0070 0.2948 rs7926354 0.0001 0.0033 rs11512743
16p11.2 0.0809 0.7554a rs889555 0.1608 0.7843a rs8050588
17q21.31 0.1041 0.4977 rs2532276 0.1068 0.5140 rs58879558
19q13.32 0.0208 0.9792a rs114536010 0.0277 0.0984 rs157595b

LBD Lewy body dementia, AD Alzheimer’s disease, PD Parkinson’s disease, PP posterior probability; PP3 PP of both traits are associated but with distinct causal variants, PP4 PP of both traits are associated and share a single causal variant, Best causal SNP with the highest PP4 is considered to be the causal variant in the genomic risk loci

aPP3 or PP4 larger than 0.75

bThe potential causal SNP was the top SNP in the locus