Table 4.
Summary of colocalization results in 13 genomic risk loci
Chromosome loci | LBD-AD | LBD-PD | ||||
---|---|---|---|---|---|---|
PP3 | PP4 | Best Causal | PP3 | PP4 | Best causal | |
1q22 | 0.0064 | 0.0370 | rs35603727b | 0.0105 | 0.9893† | rs35603727b |
2q14.3 | 0.0002 | 0.9998a | rs4663105 | 0.0198 | 0.1529 | rs4663105 |
4p16.3 | 0.0213 | 0.4839 | rs34311866b | 0.0023 | 0.9976a | rs34311866b |
4q22.1 | 0.0432 | 0.5154 | rs7680557 | 1.0000a | 0.0000 | rs356203 |
5q12.1 | 0.0001 | 0.0012 | rs4647170 | 0.0212 | 0.3983 | rs75646569 |
5q33.3 | 0.0023 | 0.1630 | rs6555853 | 0.0002 | 0.0168 | rs9790947b |
6p21.1 | 0.0014 | 0.2463 | rs34346157 | 0.0002 | 0.0602 | rs13216201b |
8p21.1 | 0.0009 | 0.8264a | rs1532278b | 0.0000 | 0.0400 | rs1532276 |
10p14 | 0.0012 | 0.4398 | rs7920721 | 0.0000 | 0.0021 | rs11257240b |
11q12.2 | 0.0070 | 0.2948 | rs7926354 | 0.0001 | 0.0033 | rs11512743 |
16p11.2 | 0.0809 | 0.7554a | rs889555 | 0.1608 | 0.7843a | rs8050588 |
17q21.31 | 0.1041 | 0.4977 | rs2532276 | 0.1068 | 0.5140 | rs58879558 |
19q13.32 | 0.0208 | 0.9792a | rs114536010 | 0.0277 | 0.0984 | rs157595b |
LBD Lewy body dementia, AD Alzheimer’s disease, PD Parkinson’s disease, PP posterior probability; PP3 PP of both traits are associated but with distinct causal variants, PP4 PP of both traits are associated and share a single causal variant, Best causal SNP with the highest PP4 is considered to be the causal variant in the genomic risk loci
aPP3 or PP4 larger than 0.75
bThe potential causal SNP was the top SNP in the locus