Table 4.

Pairwise comparison of outcome measures between different study time-points in the intervention group

Category	Time-point	Reference time-point	Mean Difference	Standard Error	P-value	95% Confidence Interval for Difference
Visual analog scale (headache severity)	1	2	1.875	0.340	< 0.001	(1.150, 2.600)
		3	2.500	0.342	< 0.001	(1.772, 3.228)
	2	3	0.625	0.352	0.096	(-0.125, 1.375)
Migraine disability assessment scale (MIDAS)	1	2	21.875	4.513	< 0.001	(12.256, 31.494)
		3	23.813	4.841	< 0.001	(13.494, 34.131)
	2	3	1.938	0.692	0.013	(0.462, 3.413)
MIDAS-A	1	2	16.938	3.269	< 0.001	(9.970, 23.905)
		3	19.563	3.217	< 0.001	(12.705, 26.420)
	2	3	2.625	1.197	0.044	(0.074, 5.176)
MIDAS-B	1	2	1.594	0.369	0.001	(0.808, 2.379)
		3	2.063	0.413	< 0.001	(1.182, 2.943)
	2	3	0.469	0.314	0.157	(-0.202, 1.139)
Headache impact test (HIT)	1	2	6.750	1.493	< 0.001	(3.568, 9.932)
		3	10.313	1.128	< 0.001	(7.908, 12.717)
	2	3	3.563	1.151	0.007	(1.109, 6.016)
Hospital anxiety and depression scale-Anxiety	1	2	2.625	0.774	0.004	(0.975, 4.275)
		3	3.688	0.762	< 0.001	(2.063, 5.312)
	2	3	1.063	0.403	0.019	(0.204, 1.921)
Hospital anxiety and depression scale-Depression	1	2	2.063	0.433	< 0.001	(1.140, 2.985)
		3	2.313	0.561	0.001	(1.118, 3.507)
	2	3	0.250	0.487	0.615	(-0.789, 1.289)
Days with headache within the past 30 days	1	2	5.625	1.179	< 0.001	(3.111, 8.139)
		3	8.125	1.541	< 0.001	(4.841, 11.409)
	2	3	2.500	1.114	0.040	(0.125, 4.875)
Number of pain-relievers taken during the past 30 days	1	2	7.188	1.085	< 0.001	(4.875, 9.500)
		3	8.688	1.413	< 0.001	(5.675, 11.700)
	2	3	1.500	0.764	0.068	(-0.128, 3.128)

Results based on estimated marginal means