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. 2022 Jun 21;23:243. doi: 10.1186/s12859-022-04786-9

Fig. 1.

Fig. 1

Method Overview. a OTUs in a sample are displayed. b OTUs are divided into sets/blocks by biological group (Genus, Family, Order, Class). c Within each set, a tree-based method is utilized to obtain the importance measure of each OTU and form a ranking of OTUs in terms of their marginal contribution to the disease status. d Empirically determine the number of top OTUs to form a super-taxon. e Top OTUs within each set/block are then aggregated into a super-taxon (STB and STC are both considered for OTU presence or abundance)