Fig. 6. The effects of sPRR-His and Losartan on vasorelaxation function in DIO mice or lean mice.
Percentage (%) vasorelaxation to acetylcholine (A&C) and sodium nitroprusside (B&D) were measured using isometric tension procedures. Comparison of one time point among groups was made using one-way ANOVA. Comparison of multiple time points among groups was made using one-way or two-way repeated-measures ANOVA. Tukey post hoc tests were performed when significant main effects were obtained. *P<0.05, compared with DIO+ sPRR-His. For A and B, N=6–8 per group. For C and D, N=8 per group. Data are mean ± SEM.