Table 1:

Model parameters (dimensional)

Parameter	Description	Value	Unit
Reference variables
T*	Time	104	s
L*	Length	10−2	m
u*	Velocity	10−6	m/s
D*	Diffusion	10−8	m2/s
ρ*	ECM density	1	kg/m3
G*	Protease	10−4	kg/m3
C*	Chemokine	10−4	kg/m3
H*	TGF	10−4	kg/m3
P*	Pressure	104	Pa
ρM	Maximum ECM density	ρ*	kg/m3
GM	Maximum protease density	0.5G*	kg/m3
CM	Maximum chemokine density	0.3G*	kg/m3
HM	Maximum TGF density	0.5H*	kg/m3
Material constants
DG	diffusion coefficient of protease	8 · 10−12	m2/s
DC	diffusion coefficient of chemokine	7 · 10−14	m2/s
DH	diffusion coefficient of TGF	8 · 10−12	m2/s
Production/decay rates
λ 21	degradation of ECM	10	m3/kgs
λ 22	reconstruction of ECM	1.25 · 10−3	1/s
λ 23	release of ECM	0	1/s
λ 24	release of ECM	1.25 · 10−3	1/s
λ 31	decay of protease	2.5 · 10−3	1/s
λ 32	cell production of protease	2 · 10−6	kg/m3s
λ 33	logistic term constant (protease)	2 · 10−6	kg/m3s
νG	exponent in logistic function of protease	1	-
λ 41	proteolytically freed chemokine	3.2 · 10−3	m3/kgs
λ 42	logistic term constant (chemokine)	1.44 · 10−4	m3/kgs
λ 43	logistic term constant (chemokine)	3.2 · 10−3	m3/kgs
λ 44	cell consumption of chemokine	1 · 10−9	1/s
νC	exponent in logistic function of chemokine	0.2	-
λ 51	decay of TGF	1 · 10−5	1/s
λ 52	production of TGF	8.75 · 10−7	kg/m3s
λ 53	logistic term constant (TGF)	5.5 · 10−7	kg/m3s
λ 54	logistic term constant (TGF)	0	kg/m3s
λ 55	fibroblast consumption of TGF	2 · 10−6	1/s
νH	exponent in logistic function of TGF	0.2	-
Potential function, chemokine
ξC	parameter characterizing ΛC	8 · 104	m3/kg
ΛC0	parameter characterizing ΛC	0	Pa
ΛC1	parameter characterizing ΛC	2.5 · 104	Pa
Potential function, TGF
ξH	parameter characterizing ΛH	1.6 · 105	m3/kg
ΛH0	parameter characterizing ΛH	0	Pa
ΛH1	parameter characterizing ΛH	2.5 · 104	Pa
Capillary pressure function
γ	parameter characterizing ΔP	103	Pa
δ	parameter characterizing ΔP	0.01	-