Fig. 6. IL-17A-mediated activation of different immunopathological factors. A. Covid-19 infection leading to pleural effusion, alveolar oedema, and pulmonary fibrosis. B. Signalling transduction of IL-17A at alveolar epithelial cells of the lung. IL-17 induces inflammation by acting in synergy with IL-6, IL-1 and TNF and by expressing chemokines such as CXCL1, CXCL5, and MMPs as it is not a potent inducer of inflammatory response. Along with other chemokines and cytokines IL 17A generates a powerful inflammatory signal that results in a cytokine storm. C. Complications due to the cytokine storm in Covid 19 patients.
