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. 2021 Jun 17;118(7):1713–1727. doi: 10.1093/cvr/cvab208

Figure 3.

Figure 3

GCV treatment of p16-3MR mice does not affect atherosclerosis, but induces inflammation. (A) Aortic root plaques in ApoE→ApoE, p16→ApoE, ApoE→p16, or p16→p16 mice + GCV, or p16→p16 mice + saline, stained with Masson’s trichrome, TUNEL, or Mac3. Scale bar = 300 µm. High power inset shows apoptotic cell and nuclear debris from outlined area. (B) Plaque area for mice in (A). (C and D) Number of TUNEL+ cells/aortic root plaque (C) or %Mac3+ cells (D) for mice in (A). (E–G) Relative mRNA expression for p16, IL18, or TNFα in experimental mice. Data are means (SD) n = 5–10 mice. One-way ANOVA with correction for multiple comparisons (B–D) or Kruskal–Wallis H test followed by Dunn’s multiple comparisons test (E–G).