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. 2021 Jun 4;118(7):1805–1820. doi: 10.1093/cvr/cvab187

Figure 1.

Figure 1

Combined loss of Bmp9 and Bmp10 leads to cardiomegaly, splenomegaly, and pulmonary hemosiderosis in DKO mice. Heart weight (A) and spleen weight (B) normalized to body weight and representative photographs of hearts (C) and spleens (D) (n = 11–12/group, male mice, scale bar = 4 mm). Representative photomicrographs of H&E-stained transverse heart sections (E) and quantitative analysis of the left ventricle + septum (LV+S), right ventricle (RV), and total cardiac tissue area (F) (n = 4/group, female mice, scale bar = 2 mm). Representative photomicrographs of fresh lungs (scale bar = 2 mm) (G) and lung sections stained with Prussian blue (scale bar = 200 µM) (H). All mice were injected with tamoxifen at the age of 2 months and euthanized at the age of 5 months. Data are presented as the means ± SEM and were analysed using Kruskal–Wallis tests followed by Dunn’s tests. *P < 0.05, ****P < 0.0001 vs. WT; #P < 0.05, ##P < 0.01 vs. Bmp9-KO; $P < 0.05, $$P < 0.01 vs. Bmp10-cKO.