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. 2021 Jun 4;118(7):1805–1820. doi: 10.1093/cvr/cvab187

Figure 5.

Figure 5

Bmp9-KO, Bmp10-cKO, and DKO mice do not develop spontaneous PH under normoxic conditions and exhibit different susceptibility to the development of chronic hypoxia induced PH and cardiac remodelling. (A, D, G) Values of right ventricular systolic pressure (RVSP), (B, E, H) right ventricular hypertrophy, expressed by the Fulton Index RV/(LV+S), (C, F, I), and of heart weight of WT vs. Bmp9-KO mice (A–C), WT vs. BMP10-cKO mice (D–F), and WT vs. DKO mice (G–I). Data are presented as the means ± SEM of n = 5–10 male mice per group and were analysed using by ANOVA followed by Tukey’s test. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. WT under normoxia; #P < 0.05, ###P < 0.001, ####P < 0.0001 vs. WT under chronic hypoxia. AU, arbitrary unit; LV, left ventricle; ns, non-significant; RV, right ventricle; S, septum.