Figure 6.

Loss of Bmp9 but not Bmp10 decreases the susceptibility of developing of chronic hypoxia-induced PH, as it protects against pulmonary arterial remodelling. Representative images of haematoxylin-eosin (H&E) staining and α-smooth muscle (SM)-actin and quantification of the percentage of muscularized and wall thickness of distal pulmonary arteries in the lungs of WT vs. Bmp9-KO mice (A), WT vs. Bmp10-cKO mice (B), and WT vs. DKO mice (C). Scale bar = 50 µm for all sections. Data are presented as the means ± SEM of n = 5–9 male mice per group and were analysed by ANOVA followed by Tukey’s test. *P < 0.05, ****P < 0.0001 vs. WT under normoxia; ^###P < 0.001, ^####P < 0.0001 vs. WT under chronic hypoxia.