Table 4.
Association between serum immunoglobulins and risk of incident pneumonia.
| N events/total | Hazard Ratio (95% Confidence Interval) | ||||
|---|---|---|---|---|---|
| Follow-up time | Model 1 | Model 2 | Model 3 | ||
| 0-3 years | IgA | 92/8,722 | 0.95 (0.78-1.16) | 0.95 (0.78-1.16) | 0.94 (0.77-1.15) |
| IgG | 92/8,712 | 1.01 (0.93-1.10) | 1.02 (0.93-1.10) | 1.02 (0.94-1.10) | |
| IgM | 92/8,718 | 1.08 (0.98-1.19) | 1.08 (0.98-1.19) | 1.08 (0.98-1.19) | |
| 3-6 years | IgA | 176/8,255 | 0.97 (0.84-1.12) | 1.00 (0.87-1.16) | 0.98 (0.84-1.13) |
| IgG | 176/8,245 | 0.99 (0.92-1.05) | 1.01 (0.94-1.07) | 1.00 (0.94-1.07) | |
| IgM | 175/8,251 | 1.00 (0.87-1.14) | 1.00 (0.87-1.14) | 1.00 (0.87-1.14) | |
| >6 years | IgA | 160/7,546 | 1.15 (1.00-1.32) | 1.18 (1.03-1.36) | 1.15 (1.00-1.32) |
| IgG | 160/7,536 | 1.10 (1.04-1.17) | 1.12 (1.06-1.19) | 1.13 (1.06-1.19) | |
| IgM | 160/7,543 | 0.98 (0.84-1.15) | 0.98 (0.85-1.14) | 0.98 (0.85-1.14) | |
Model 1 was adjusted for age, sex, and Rotterdam Study cohort; Model 2 was adjusted for model 1, smoking status, pack years, and alcohol consumption; Model 3 was adjusted for model 2, BMI, DM, asthma, COPD, hypertension, physical activity, and serum CRP.
N events/total refers to the number of participants with incident pneumonia and the total number of participants included in the analyses.
Significant associations (P <0.05) are in bold.
IgA/IgG/IgM, immunoglobulin A/G/M; BMI, body mass index; DM, diabetes mellitus; COPD, chronic obstructive pulmonary disease; CRP, C-reactive protein.