Table 5.
Association between serum immunoglobulins and lung function values or spirometry patterns.
| FEV1% predicted | ||||
|---|---|---|---|---|
| Beta (95% Confidence Interval) | ||||
| Total N | Model 1 | Model 2 | Model 3 | |
| IgA | 3,960 | -0.35 (-1.03 – 0.34) | -0.88 (-1.54 – -0.22) | -0.76 (-1.42 – -0.10) |
| IgG | 3,957 | -0.45 (-0.74 – -0.15)* | -0.88 (-1.16 – -0.59) | -0.85 (-1.14 – -0.57) |
| IgM | 3,960 | 0.50 (-0.13 – 1.14) | 0.43 (-0.18 – 1.04) | 0.37 (-0.24 – 0.97) |
| FVC % predicted | ||||
| Beta (95% Confidence Interval) | ||||
| Total N | Model 1 | Model 2 | Model 3 | |
| IgA | 3,960 | -0.59 (-1.17 – -0.01) | -0.87 (-1.44 – -0.30) | -0.69 (-1.25 – -0.12) |
| IgG | 3,957 | -0.55 (-0.80 – -0.30) | -0.78 (-1.03 – -0.53) | -0.73 (-0.98 – -0.49) |
| IgM | 3,960 | 0.30 (-0.23 – 0.84) | 0.27 (-0.26 – 0.79) | 0.18 (-0.34 – 0.70) |
| FEV1/FVC ratio (Tiffeneau index) | ||||
| Beta (95% Confidence Interval) | ||||
| Total N | Model 1 | Model 2 | Model 3 | |
| IgA | 3,960 | 0.32 (0.06 – 0.57)* | 0.13 (-0.11 – 0.38) | 0.08 (-0.16 – 0.32) |
| IgG | 3,957 | 0.24 (0.14 – 0.35)* | 0.10 (-0.00 – 0.21)* | 0.09 (-0.02 – 0.19)* |
| IgM | 3,960 | 0.10 (-0.13 – 0.34) | 0.08 (-0.15 – 0.30) | 0.10 (-0.13 – 0.32) |
| PRISm | ||||
| Odds Ratio (95% Confidence Interval) | ||||
| Total N | Model 1 | Model 2 | Model 3 | |
| IgA | 3,960 | 1.13 (0.99 – 1.28) | 1.17 (1.03 – 1.33) | 1.14 (1.00 – 1.31) |
| IgG | 3,957 | 1.09 (1.03 – 1.15) | 1.11 (1.05 – 1.18) | 1.11 (1.05 – 1.17) |
| IgM | 3,960 | 0.90 (0.74 – 1.09) | 0.90 (0.74 – 1.10) | 0.92 (0.75 – 1.11) |
| COPD | ||||
| Odds Ratio (95% Confidence Interval) | ||||
| Total N | Model 1 | Model 2 | Model 3 | |
| IgA | 8,765 | 1.00 (0.87-1.16) | 1.07 (0.92-1.24) | 1.07 (0.93-1.24) |
| IgG | 8,755 | 0.90 (0.84-0.97) | 0.94 (0.88-1.01) | 0.94 (0.88-1.01) |
| IgM | 8,761 | 0.99 (0.88-1.12) | 1.00 (0.88-1.13) | 1.00 (0.88-1.13) |
*Non-linear association.
Model 1 was adjusted for age, sex, and time interval between blood drawing and spirometry; Model 2 was adjusted for model 1, smoking status, and pack years; Model 3 was adjusted for model 2, BMI, DM, hypertension, and physical activity.
Significant associations (P <0.05) are in bold.
IgA/IgG/IgM, immunoglobulin A/G/M; FEV1, forced expiratory volume in one second; FVC, forced vital capacity; PRISm, preserved ratio impaired spirometry; COPD, chronic obstructive pulmonary disease; BMI, body mass index; DM, diabetes mellitus.