. 2022 May 31;96(12):e00320-22. doi: 10.1128/jvi.00320-22

TABLE 2.

Transmission reduction from antibody-deficient immunized mice

Mouse strain	Donor immunization	No. of infected BALB/c donors at day 4/total no. of donors (mean titer ± SEM)			No. of infected CFW contacts/total no. of contacts (mean titer ± SEM)			% Reduction in transmission vs B/NP-rAd
Mouse strain	Donor immunization	Lung (log₁₀TCID₅₀/mL)	Nasal wash (Log₁₀TCID₅₀/mL)	Total (%)	Lung (log₁₀TCID₅₀/mL)	Nasal wash (Log₁₀TCID₅₀/mL)	Total (%)	% Reduction in transmission vs B/NP-rAd
BALB/c	A/NP+M2-rAd	1/16 (2.45)	4/16 (2.51 ± 0.06)	5/16 (31.3)	1/24 (2.45)	0/24	1/24 (4.2)	95.2 (P < 0.001)
BALB/c	B/NP-rAd	16/16 (6.27 ± 0.11)	16/16 (3.77 ± 0.17)	16/16 (100)	9/24 (4.95 ± 0.54)	21/24 (3.89 ± 0.24)	21/24 (87.5)
mIgTg-J_HD^−/−	A/NP+M2-rAd	20/22 (4.44 ± 0.32)	20/22 (3.10 ± 0.12)	22/22 (100)	0/33	0/33	0/33 (0)	100 (P < 0.001)
mIgTg-J_HD^−/−	B/NP-rAd	22/22 (6.00 ± 0.22)	22/22 (4.28 ± 0.17)	22/22 (100)	7/33 (4.15 ± 0.44)	15/33 (3.36 ± 0.19)	18/33 (54.6)