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. Author manuscript; available in PMC: 2022 Jun 22.
Published in final edited form as: Clin Cancer Res. 2021 Feb 4;27(8):2266–2276. doi: 10.1158/1078-0432.CCR-20-3882

Figure 6. Biochemical analysis of irradiated mouse heart tissue segments and human plasma.

Figure 6.

A, Effects of focal cardiac RT on markers of cardiovascular injury and inflammation at 1, 2, 4, and 8 weeks post 40 Gy PH, 40 Gy PHL, and 60 Gy PH RT (n= 3 or 4 per group unless otherwise noted). P<0.05, **P<0.01, ***P<0.001 (details in Supplementary Table S3). Cardiac tissue levels of troponin I were above detection range of assay. B, Effects of thoracic RT in lung cancer patients on PlGF and TNFα and correlation of fold change in these markers with mean heart dose. C, Comparison of PlGF and TNFα changes in lung versus breast cancer patients. Data are from 14 lung cancer patients and 32 breast cancer patients. Missing data is due to undetectable marker levels in several plasma samples.