1. Changed decisions in study eligibility assessment.
| Study ID | Status in this review update | Status in the previous review | Reason for change of decision |
| Faisal 2020 | Excluded | Awaiting classification | Study did not pass research integrity check*, due to lack of trial registration; author did not provide clarification regarding the trial design. Presumably, it is not a RCT. |
| Samaha 2021 | Excluded | Awaiting classification | Trial did not pass research integrity check*, due to published retraction notice |
| Abd‐Elsalam 2021 | Excluded | Ongoing | Trial did not pass research integrity check*, due to retrospective trial registration |
| Biber 2021 | Excluded | Ongoing | Trial did not pass research integrity check*, due to retrospective trial registration |
| Ahmed 2020 | Excluded | Included | Trial did not pass research integrity check*, due to lack of trial registration |
| Chachar 2020 | Excluded | Included | Trial did not pass research integrity check*, due to retrospective trial registration |
| Kishoria 2020 | Excluded | Included | Trial did not pass research integrity check*, due to lack of trial registration |
| Okumuş 2021 | Excluded | Included | Trial did not pass research integrity check*, due to retrospective trial registration |
| Podder 2020 | Excluded | Included | Trial did not pass research integrity check*, due to lack of trial registration |
| Shah Bukhari 2021 | Excluded | Included | Trial did not pass research integrity check*, retrospective trial registration |
| Shouman 2021 | Excluded | Included | Trial did not pass research integrity check*, due to wrong study design; direct contact with the author revealed that the study is not a RCT. |
| Vallejos 2021 | Included | Ongoing | New full‐text journal publication |
| Bounfrate 2021 | Included | Ongoing | New preprint and pre‐proof journal publication |
| IRCT20190624043993N2 | Awaiting classification | Ongoing | Meanwhile completed, no results published |
| IRCT20200404046937N4 | Awaiting classification | Ongoing | Meanwhile completed, no results published |
| NCT04602507 | Awaiting classification | Ongoing | Meanwhile terminated, interim results might be published in the future |
| NCT04673214 | Awaiting classification | Ongoing | Trial did not pass research integrity check* yet, because relevant information to assure trustworthiness is missing. Trialist was contacted for clarification. Only a partial response was received which could not fully clarify the issue up until now. |
| NCT04894721 | Awaiting classification | Ongoing | Meanwhile completed, no results published |
| PACTR202102588777597 | Awaiting classification | Ongoing | Meanwhile terminated, interim might be published in the future |
| IRCT20111224008507N4 | Awaiting classification | Ongoing | Meanwhile completed, no results published |
| TOGETHER 2022 | Included | Ongoing | New full‐text journal publication |
*Details of the research integrity check can be found in Figure 1 and Supplementary File_Ivermectin_Research Integrity. RCT: randomized controlled trial.