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. 2022 Jun 21;2022(6):CD015017. doi: 10.1002/14651858.CD015017.pub3

Risk of bias for analysis 2.12 Viral clearance at day 14.

Study Bias
Randomisation process Deviations from intended interventions Missing outcome data Measurement of the outcome Selection of the reported results Overall
Authors' judgement Support for judgement Authors' judgement Support for judgement Authors' judgement Support for judgement Authors' judgement Support for judgement Authors' judgement Support for judgement Authors' judgement Support for judgement
Bounfrate 2021 Low risk of bias Centralized web‐based randomization. There are no baseline differences that would suggest a problem with randomization. Low risk of bias Both participants and those delivering the intervention were not aware of the intervention received and the analysis was appropriate. Low risk of bias Data for this outcome were reported for nearly all participants that were randomised, were symptomatic at baseline and did not withdraw consent before the study start. Low risk of bias Outcome assessors were not aware of the intervention received. Knowledge of intervention received could not have affected outcome measurement. Low risk of bias The protocol was prospectively registered and the outcome in the journal publication was reported as registered. Low risk of bias Due to low risk of bias in all domains.
Vallejos 2021 Low risk of bias Randomization was performed by an team member who was not part of any other part of the study using a computer‐based programme. There was no baseline imbalance that would suggest a problem with randomization. Low risk of bias Both participants and those delivering the intervention were not aware of the intervention received and the analysis was appropriate. Low risk of bias Data for this outcome were available for all randomized participants. Low risk of bias Outcome assessors were not aware of the intervention received. Knowledge of intervention received could not have affected outcome measurement. Low risk of bias The protocol was prospectively registered and the outcome in the journal publication was reported as registered. Low risk of bias Due to low risk of bias in all domains.