TABLE 2.
Outcomes among hospitalized solid organ transplant recipients with COVID-19 (lung vs. non-lung)
| Lung (n = 120) | Non-lung (n = 961) | p value | |
|---|---|---|---|
| Death by 28 days | 29 (24.2) | .032* | |
| ICU admission | 52 (43.7) | ||
| Mechanical ventilation | 33 (27.5) | ||
| Extracorporeal membrane oxygenation | |||
| Acute kidney injuryab | 40 (33.3) | 394 (41.0) | |
| Bacterial pneumoniac | 12 (10.0) | 72 (7.5) | |
| Fungal pneumoniad | 3 (2.5) | 4 (0.4) | .01* |
| Bloodstream infectione | 2 (1.7) | 52 (5.4) | .08 |
| Acute cellular rejection | 2 (1.7) | 9 (1.0) | .45 |
ICU admission status was available for 119 lung and 925 non-lung recipients.
Acute kidney injury defined as >50% increase in creatinine from baseline.
Includes cases in which a pathogen was isolated on respiratory culture; excludes empirically treated cases. Respiratory bacterial pathogens in lung recipients included Pseudomonas spp. (n = 10), Klebsiella spp. (n = 1), Escherichia coli (n = 1), Stenotrophomonas maltophilia (n = 1). Pathogens in non-lung recipients included Pseudomonas (n = 24), Klebsiella spp. (n = 11), E. coli (n = 7), Stenotrophomonas maltophila (n = 4), Burkholderia spp. (n = 5), Citrobacter spp. (n = 3), Enterobacter spp. (n = 3), Acinetobacter spp. (n = 2), Proteus spp. (n = 1), Achromobacter spp. (n = 1), Hafnia spp. (n = 1), Capnocytophyga spp.(n = 1), Staphylococcus aureus (n = 25), and Streptococcus spp. (n = 5). Some patients had more than one pathogen isolated.
Includes cases in which a pathogen was identified; excludes diagnoses based on galactomannan or imaging findings alone. Aspergillus was isolated in 2 lung recipients and 3 non-lung recipients. One non-lung recipient had Rhizopus and one non-lung recipient had Cryptococcus.
Bloodstream pathogens in lung recipients included Stenotrophomonas maltophila (n = 1) and Enterococcus spp. (n = 1). Bloodstream pathogens in non-lung recipients included Pseudomonas spp. (n = 8), E. coli (n = 10), Enterobacter spp. (n = 2), Stenotrophomonas maltophila (n = 1), Proteus spp. (n = 1), Staphylococcus aureus (n = 22), Streptococcus spp. (n = 1), Enterococcus spp. (n = 8), and Candida spp. (n = 6). Excludes possible contaminants: coagulase-negative staphylococcus (0 lung, 18 non-lung recipients) Bacillus spp (1 non-lung recipient), and Corynebacterium spp (1 non-lung recipient).
Statistically significant at ≤ .05.