TABLE 2.
REACTOME pathways with the genes differentially expressed in infant tissues with adjusted p values <0.001 compared with adults and for adult tissues with adjusted p values <0.001 compared with infants.
| Increased in infants | p value | Increased in adults | p value |
|---|---|---|---|
| Extracellular matrix organization | 1.00E-28 | Keratinization | 1.01E-23 |
| Degradation of the extracellular matrix | 5.62E-19 | Formation of the cornified envelope | 2.36E-23 |
| ECM proteoglycans | 1.51E-17 | Developmental Biology | 1.79E-08 |
| Collagen formation | 9.23E-16 | Interferon gamma signaling | 4.00E-06 |
| Collagen biosynthesis and modifying enzymes | 2.54E-13 | Endosomal/Vacuolar pathway | 8.29E-06 |
| Assembly of collagen fibrils and other multimeric structures | 6.27E-13 | ||
| Collagen chain trimerization | 1.35E-12 | ||
| Collagen degradation | 3.86E-11 | ||
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | 2.12E-10 | ||
| Integrin cell surface interactions | 3.53E-09 | ||
| Post-translational protein phosphorylation | 1.59E-07 | ||
| Crosslinking of collagen fibrils | 3.76E-07 | ||
| Non-integrin membrane-ECM interactions | 5.64E-07 | ||
| MET activates PTK2 signaling | 1.9735E-06 | ||
| Laminin interactions | 1.9735E-06 | ||
| NCAM1 interactions | 3.2334E-06 | ||
| Metal sequestration by antimicrobial proteins | 7.9462E-06 | ||
| MET promotes cell motility | 3.1644E-05 | ||
| Signaling by PDGF | 4.2549E-05 | ||
| Signaling by receptor tyrosine kinases | 6.1897E-05 |