Table 1.

Demographic and clinical characteristics of HC and AD/MCI participants in the independent cohort.

	HC (n=25)	AD/MCI (n=19)	p-value
Age (years)a	70.2 ± 4.8	72.9 ± 1.7	0.138
Sex (% male)b	56%	37%	0.208
TIV (cm3)c	1480.8 ± 142.3	1500.8 ± 204.0	0.606
Education (years)a	17.0 ± 2.1	15.6 ± 2.4	0.037*
MMSEc	29.8 ± 0.4	22.3 ± 7.0	<0.001*
BDI-IIc	3.9 ± 4.7	8.9 ± 7.1	0.012*
AES totalc	24.6 ± 5.8	34.1 ± 14.2	0.004*
AES cognitivec	10.9 ± 2.8	14.8 ± 6.5	0.011*
AES behaviorc	6.6 ± 1.7	9.7 ± 3.9	0.002*
AES emotionalc	2.9 ± 1.0	3.5 ± 1.9	0.498

Note:

^*p<0.05;

^atwo-sample t-test;

^bchi-square test,

^ctwo-sample Wilcoxon rank-sum (Mann-Whitney) test;

TIV: total intracranial volume, MMSE: Mini mental state examination, BDI: Beck Depression Inventory, AES: Apathy Evaluation Scale