Table 3.
Rimonabant Antagonism (Kb) of Cannabinoid G-Protein Activation in Mouse Membranes
| Drug | IC50 (nM) | K b (nM) | pKb (−log Kb) | N | Rimonabant Pre-Incubation |
|---|---|---|---|---|---|
| THC | 9.27 | 0.32 | 9.50 ± 0.06a | 5 | None |
| 5F-MDMB-PINACA | 37.9 | 0.98 | 9.01 ± 0.05b | 7 | None |
| M2 | 11.7 | 0.30 | 9.53 ± 0.04a | 4 | None |
| M7 | .913 | 0.27 | 9.56 ± 0.09a | 4 | None |
| 5F-MDMB-PINACA | 43.8 | 0.83 | 9.08 ± 0.04a | 5 | 10 min |
| M2 | 10.4 | 0.30 | 9.53 ± 0.08b | 4 | 10 min |
a,b
pKb values designated by different letters are significantly different from values in the same column (one-way ANOVA, Tukey’s post hoc test, p < 0.05).