Table 5.

Candidate Biomarker Ranking

Protein	AUC	Specificity (%) at 90% Sensitivity	Sensitivity (%) at 90% Specificity	PTP+ (%) at 90% Sensitivity
Increaseda
LDHA/LDH-M	0.91	80	60	66
FBP2	0.88	70	80	56
ANP32A	0.87	80	80	66
FBP1	0.87	70	70	56
QDPR	0.87	60	70	49
RIDA	0.86	40	70	39
FABP1	0.84	50	60	44
ADH1B	0.8	50	40	44
ADH1A	0.79	30	30	44
MDH1	0.78	70	30	56
IDH1	0.76	70	30	56
ASS1	0.74	50	50	44
HIST1H4A	0.69	70	0	56
Decreasedb
APOC2	0.88	70	60	56
FVII	0.87	70	70	56
PSMD11	0.8	40	50	39
Reference markers
MELD	0.47	20	13	31
ALT	0.39	0	10	0

PTP calculation is based on 30% pretest probability of death.

Abbreviations: PTP+, positive posttest probability.

^aIncreased ≥4-fold in ALF survivors versus controls and ≥4-fold further in nonsurvivors versus survivors.

^bDecreased ≥4-fold in ALF survivors versus controls and ≥4-fold further in nonsurvivors versus survivors.