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. Author manuscript; available in PMC: 2022 Jun 22.
Published in final edited form as: Wiley Interdiscip Rev Dev Biol. 2019 Dec 11;9(3):e371. doi: 10.1002/wdev.371

FIGURE 1.

FIGURE 1

Overview of the Hippo-Yap/Taz signaling pathway. Core components of the mammalian Hippo pathway and their regulation through phosphorylation events. (Left, canonical Hippo pathway): Hippo signaling inactive, nuclear Yap/Taz accumulation and activation of TEAD-mediated transcriptional programs. Yap/Taz phosphorylation by the Hippo kinases (ultimately by Lats1/2) leading to cytoplasmic sequestration for interactions with other pathways, degradation and other functions (bottom). Mst1/2 and Lats1/2 are also activated by non-canonical kinases Tao-1, PKA and MAP4K (top and right)