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. Author manuscript; available in PMC: 2022 Jun 22.
Published in final edited form as: Wiley Interdiscip Rev Dev Biol. 2019 Dec 11;9(3):e371. doi: 10.1002/wdev.371

FIGURE 4.

FIGURE 4

Regulation Yap/Taz subcellular localization by Cell-ECM signaling and the actin cytoskeleton. (a) Yap/Taz phosphorylation/cytoplasmic sequestration is favored in the context of a relaxed Actin fiber cytoskeleton (1), which stimulates Mer or PKA activity, promoting Mst1/2 and Lats1/2 activity, respectively (2). (b) Integrin-mediated Yap/Taz nuclear accumulation. Actin-dependent regulation of Yap/Taz subcellular localization: mechanotransduction through Rho or Src-MAPK activity (3), leading to stretching or accumulation of actin fibers (4). Actin-independent mechanisms: Integrin-ILK or integrin-FAK-induced Src blocking Mer activity (5). Src tyrosine phosphorylation of Yap also induces Yap transcriptional activity (6). Yap/Taz induction of laminin expression and basement membrane deposition (7)