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. Author manuscript; available in PMC: 2023 Aug 1.

Published in final edited form as: J Inorg Biochem. 2022 May 20;233:111869. doi: 10.1016/j.jinorgbio.2022.111869

Table 1.

IC₅₀ and K_i values with standard deviation for all reported probes for NDM-1, VIM-2, and IMP-1

	IC₅₀ (μM)			K_i (nM)

Compound	NDM-1	VIM-2	IMP-1	NDM-1	VIM-2	IMP-1
DMAP-H	12.9 ± 0.6	0.24 ± 0.05	0.47 ± 0.04	280 ± 10	60 ± 10	75 ± 6
DMAP-COOH	N/A^a	1.26 ± 0.05	1.5 ± 0.2	N/A^a	300 ± 10	240 ± 30
DMAP-COOMe	7.9 ± 0.8	0.18 ± 0.03	0.032 ± 0.005	170 ± 20	44 ± 7	5.2 ± 0.8
DMAP-COOEt	7.9 ± 0.6	0.13 ± 0.02	0.026 ± 0.003	170 ± 10	32 ± 5	4.2 ± 0.5
DMAP-COOiPr	10.3 ± 0.5	0.32 ± 0.05	0.035 ± 0.006	220 ± 10	80 ± 10	5.6 ± 1.0
DMAP-CONH₂	10.0 ± 0.7	1.7 ± 0.2	0.51 ± 0.07	220 ± 20	410 ± 50	80 ± 10
DMAP-CONHMe	8.2 ± 0.5	2.3 ± 0.2	0.48 ± 0.06	180 ± 10	560 ± 50	80 ± 10
DMAP-PCA	>150	>30	>50	>3000	>3000	>3000
DMN-H	2.4 ± 0.4	0.110 ± 0.004	0.23 ± 0.02	52 ± 9	27.0 ± 1.0	37 ± 3
DMN-COOH	N/A^a	0.69 ± 0.05	1.02 ± 0.05	N/A^a	170 ± 10	164 ± 8
DMN-COOMe	9.5 ± 0.6	0.41 ± 0.09	0.09 ± 0.01	200 ± 10	100 ± 20	15 ± 2

^a

Data not fitted due to observed partial inhibition.