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. Author manuscript; available in PMC: 2022 Jun 22.
Published in final edited form as: Nat Metab. 2021 May 27;3(6):786–797. doi: 10.1038/s42255-021-00400-z

Extended Data Fig. 1 |. Secreted proteins positively related to bone homeostasis and baseline Vo2max.

Extended Data Fig. 1 |

Functional representation of proteins’ role in bone metabolism and homeostasis. Left and middle: SMOC1 regulates osteoblast differentiation. BMPs are related to bone formation via the TGF-β pathway and are mediated by extracellular signalling molecules such as NOG. Right: simplified schematic of proteins related to cartilage formation and their location within cartilage tissue.