Table 2 |.
Proteins associated with baseline or ΔVo2max in HERiTAGE and all-cause mortality in the FHS offspring Study
| Gene name | Protein name | Adjusted HR | 95% Cl | FDR q value | Variation explained by protein (%) | |
|---|---|---|---|---|---|---|
| Baseline VO2max | ||||||
| GSNa | Gelsolin | 0.71 | 0.65 | 0.78 | 9.1 × 10–13 | 3.00 |
| CRPa | C-reactive protein | 1.24 | 1.13 | 1.36 | 8.2 × 10–5 | |
| B2Ma | β2-microglobulin | 1.21 | 1.09 | 1.33 | 1.6 × 10–3 | 1.00 |
| ECM1a | Extracellular matrix protein 1 | 0.84 | 0.77 | 0.93 | 2.9 × 10–3 | |
| MBa–c | Myoglobin | 0.87 | 0.79 | 0.96 | 1.7 × 10–2 | 0.22 |
| FCGR3Ba–c | Low-affinity immunoglobulin gamma Fc region receptor III-B | 1.13 | 1.04 | 1.23 | 1.7 × 10–2 | |
| ACP5a–c | Tartrate-resistant acid phosphatase type 5 | 1.14 | 1.03 | 1.27 | 3.1 × 10–2 | 0.17 |
| PLGa | Plasminogen | 0.90 | 0.82 | 0.98 | 4.4 × 10–2 | 0.45 |
| NRCAMa,b | Neuronal cell adhesion molecule | 0.90 | 0.83 | 0.98 | 4.6 × 10–2 | - |
| CFBa | Complement factor B | 1.11 | 1.01 | 1.22 | 5.4 × 10–2 | - |
| ENPP7a–c | Ectonucleotide pyrophosphatase/phosphodiesterase family member 7 | 1.11 | 1.01 | 1.21 | 5.4 × 10–2 | - |
| NRXN3a | Neurexin-3-ß | 0.90 | 0.83 | 0.99 | 5.4 × 10–2 | - |
| ΔVO2max | ||||||
| MMP12a–c | Macrophage metalloelastase | 1.34 | 1.22 | 1.48 | 1.2 × 10–7 | 1.80 |
| FAPa–c | Prolyl endopeptidase FAP | 0.78 | 0.72 | 0.85 | 3.8 × 10–7 | |
| ANGPT2a–c | Angiopoietin-2 | 1.21 | 1.10 | 1.33 | 6.7 × 10–4 | 0.47 |
| STC1a–c | Stanniocalcin-1 | 1.19 | 1.09 | 1.30 | 1.8 × 10–3 | 0.74 |
| CCL27a,b | C-C motif chemokine 27 | 1.16 | 1.06 | 1.28 | 7.3 × 10–3 | - |
| IL11RAa | Interleukin-11 receptor subunit α | 0.86 | 0.79 | 0.94 | 7.3 × 10–3 | 0.54 |
| ERBB3a,b | Receptor tyrosine-protein kinase erbB-3 | 0.86 | 0.78 | 0.94 | 8.3 × 10–3 | 0.21 |
| ACANa,c | Aggrecan | 0.87 | 0.80 | 0.96 | 1.7 × 10–2 | - |
| IMDH2 | Inosine-5'-monophosphate dehydrogenase | 1.12 | 1.03 | 1.23 | 3.3 × 10–2 | - |
Cox proportional hazards analysis was performed for both the proteins associated with baseline VO2max and those associated with VO2max and all-cause mortality, adjusting for age, sex and batch. Proteins from each analysis that were statistically significant (FDR q < 0.1) were brought forwards in stepwise regression. The percent variation in all-cause mortality beyond age and sex is listed in the final column for those proteins retained in the final model.
Aptamer specificity supported by pQTLs and/or MS-based proteomics in population-based data (Supplementary Table 15).
Aptamer targets available for comparison on Olink Explore platform in HERITAGE subset (n = 88).
Proteins with Spearman correlation > 0.4 on aptamer and antibody-based platforms in HERITAGE subset.