. 2022 Jun 8;11(6):572–585. doi: 10.1093/stcltm/szac023

Table 2.

Changes in cartilage from baseline to 24 months based on cartilage defect area and MOCART 2.0 knee scores using MRI.

	ADMSC (n = 13)	Control (n = 13)	95% CI	P value	P value^†
Mean cartilage defect area, mm²
Baseline	205.0 ± 181.4	296.1 ± 203.0	−246.9 to 64.8	.240^a	.240^a
3 months	137.4 ± 171.7	246.3 ± 192.	−257.8 to 40.0	.144^a	.201
6 months	106.89 ± 175.4	226.5 ± 176.3	−261.9 to 22.7	.096^a	.201
18 months	90.4 ± 186.6	197.3 ± 172.9	−252.6 to 38.7	.143^a	.201
24 months	81.5 ± 186.1	178.9 ± 155.6	−236.2 to 41.5	.161^a	.201
Ratio of regenerated cartilage area, %
3 months/baseline	43.3 ± 30.1	17.4 ± 20.9	4.9 to 46.9	.018^a^,^*	.031^*
6 months/baseline	65.3 ± 40.1	27.4 ± 36.7	6.7 to 69.0	.019^a^,^*	.031^*
18 months/baseline	74.9 ± 37.9	38.5 ± 43.2	3.6 to 69.4	.031^a^,^*	.031^*
24 months/baseline	81.1 ± 34.4	44.4 ± 43.8	4.8 to 68.6	.026^*	.031^*
MOCART 2.0 knee score
3 months	40.0 ± 20.1	28.1 ± 13.6	−2.1 to 25.9	.091^a	.091
6 months	58.5 ± 26.3	33.8 ± 22.4	4.8 to 44.4	.017^a^,^*	.034^*
18 months	64.6 ± 27.5	40.4 ± 24.5	3.1 to 45.3	.026^a^,^*	.034^*
24 months	76.2 ± 23.6	50.4 ± 28.9	4.4 to 47.1	.020^a^,^*	.034^*

Values are present as mean ± SD.

Student t-test.

Mann-Whitney U test.

P-value was adjusted for multiple comparisons using the false discovery rate (FDR).

Statistical significance was set at <.05.

Abbreviations: ADMSC, adipose-derived mesenchymal stem cell; MOCART, magnetic resonance observation of cartilage repair tissue; MRI, magnetic resonance imaging.