Summary of findings 3. Comparison of antibiotics for routes of administration and duration of therapy.

Comparison of routes of administration and duration of therapy
Patient or population: Patients with acute uncomplicated diverticulitis Settings: Hospital admitted patients Intervention: Antibiotic treatment: IV AB administration Comparison: Antibiotic treatment: oral AB administration
Outcomes	Illustrative comparative risks* (95% CI)		Relative effect (95% CI)	No of Participants (studies)	Quality of the evidence (GRADE)	Comments
	Assumed risk	Corresponding risk
	Oral AB administration	IV AB administration
Primary ‐ Short‐term complications (abscess, perforation, obstruction or fistula) within 30 days						No data
Primary ‐ Short‐term emergency surgery within 30 days						No data
Secondary ‐ Recurrence during follow‐up beyond 30 days						No data
Secondary ‐Long‐term complications during follow‐up beyond 30 days	46  per 1000a	46 per 1000  (3 to 69)	RR 1.0 (0.07 to 15.00)	44 (1)	⊕⊕⊝⊝ Low	Downgraded to low due to risk of biasb and imprecisionc
Secondary ‐ Long‐term emergency surgery during follow‐up beyond 30 days						No data
Secondary ‐All cause mortality						No data
Secondary ‐ Adverse events						No data
GRADE Working Group grades of evidence High quality: Further research is very unlikely to change our confidence in the estimate of effect. Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. Very low quality: We are very uncertain about the estimate.

 ^aThe assumed risk = total events/total included in the oral AB group multiplied 1000 (1/22*1000 = 46).

^bOverall high risk of bias due to no blinding

^cHigh risk of imprecision due to few participant and no events means the quality of evidence is low