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. Author manuscript; available in PMC: 2023 Jul 1.
Published in final edited form as: Surg Oncol Clin N Am. 2022 May 31;31(3):321–340. doi: 10.1016/j.soc.2022.03.001

Table 1.

Summary of diagnostic and prognostic features of select adipocytic neoplasms.

Tumor Type Useful Diagnostic IHC Markers Characteristic Genomic Aberrations Behavior
Spindle cell/pleomorphic lipoma RB1 loss; variable expression of CD34, desmin, S100 13q14 deletion (RB1) Benign
Atypical spindle cell/pleomorphic lipomatous tumor (ASCLT/APLT) RB1 loss (50–70%); variable expression of CD34, desmin, S100 13q14 deletion (RB1) Benign; local recurrence in 10–15% if incompletely excised
Atypical lipomatous tumor (ALT)/Well-differentiated liposarcoma (WDLPS) Expression of MDM2 and/or CDK4 12q13–15 high-level amplification (MDM2, CDK4) Locally aggressive; risk of dedifferentiation
Dedifferentiated liposarcoma Expression of MDM2 and/or CDK4 12q13–15 high-level amplification (MDM2, CDK4) Malignant
Myxoid liposarcoma DDIT3 expression in high-grade cases FUS-DDIT3 gene fusion Malignant
Pleomorphic liposarcoma None None Malignant
Myxoid pleomorphic liposarcoma RB1 loss (subset) Complex chromosomal alterations Highly malignant