Table 2.
Selected studies assessing PD-L1 expression by tumor cells in thymomas and thymic carcinoma
| Technique, antibody | Thymomas |
Thymic carcinoma |
|||
|---|---|---|---|---|---|
| (n) | PD-L1 positive (n, %) | (n) | PD-L1 positive (n, %) | ||
| Katsuya et al. [29] | TMA, clone E1L3 (H-score, 1% of tumor cells cut off) | 101 | 22 (23%) | 38 | 26 (70%) |
| Padda et al. [30] | TMA, clone 5H1 (intensity high) | 65 | 44 (68%) | 4 | 3 (75%) |
| Arbour et al. [31] | Slides, clone E1L3 (25% of tumor cells cut off) | 12 | 11 (94%) | 11 | 4 (34%) |
| Yokohama et al. [32,33] | Slides, EPR1161 (H-score, 20% of tumor cells cut off) | 82 | 44 (54%) | 25 | 20 (80%) |
| Weissferdt [34] | Slides, clone E1L3 (5% of tumor cells cut off) | 74 | 47 (64%) | 26 | 14 (54%) |
| Markevski et al. [28] | Slides, clone SP142 (1% of tumor cells cut off) | 38 | 35 (92%) | 8 | 4 (50%) |
| Wei et al. [35] | TMA, clone E1L3 (% of cells and intensity) | 100 | 100 (100%: 36% low, 64 high) | 69 | 69 (100%: 64% low, 36% high) |
| Guleria et al. [36] | TMA, clone SP263 (1–25% of tumor cells cut off) | 84 | 69 (82%) | ||
| Suster et al. [37] | TMA, clone SP142 (1–50% of tumour cells cut off) | 21 (lymphoepithelioma like histology) | 15 (71%: 67% high, 33% low) | ||
| Tiseo et al. [38] | TMA, clone E1L3 (H-score, 1% of tumor cells cut off) | 87 | 16 (20%) | 25 | 13 (52%) |
| Bagir et al. [39] | Slides, clone AM26531AF-N (intensity) | 37 | 21 (57%) | 6 | 4 (67%) |
| Sakane et al. [40] | Slides, clones SP142, SP263, 22C3, Dako 28-8 (50% of tumor cells cut off) | 53 | 26–49 (49–92%) | ||
| Hakiri et al. [41] | Slides, clone SP142 (50% of tumor cells cut off) | 81 | 22 (27%) | ||
| Chen et al. [42] | TMA, clone SP142 (% of cells and intensity) | 50 | 24 (48%) | 20 | 14 (70%) |
| Terra et al. [43] | Slides, clone SP263 (1–50% of tumor cells cut off) | 11 | 10 (91%) | 6 | 2 (33%) |
| Owen et al. [44] | Slides, clone 22C3 (% of tumor cells) | 32 | 26 (81%) | 3 | 3 (100%) |
| Bedekovics et al. [45] | slides, clone SP142 (1–50% of tumor cells cut off) | 29 | 20 (69%: 70% high, 30% low) | 7 | 6 (86%: 17% high, 83% low) |
| Duan et al. [46] | Slides, clone Ab58810 (% of cells and intensity) | 13 | 13 (100%: 46% high, 64% low) | 20 | 20 (100%: 65% high, 35% low) |
| Funaki et al. [47] | Slides, multiple clones (% of cells) | 43 | 26 (60%) | ||
TMA, tissue micro-array.