Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
In vitro inhibitory activity against SARS-CoV-2 RdRp, kinetic solubility (Sk) in neutral water, microsomal stability (t1/2 micr.) in mouse, and plasma stability (t1/2 pl.) in mouse of luteolin and quercetin.
| Compound | % inhib 100 µM |
% inhib 25 µM |
IC50 (µM) |
Sk (µM) |
t1/2 micr (min) |
t1/2 pl (min) |
|---|---|---|---|---|---|---|
| Luteolin | 100 | 89 | 4.6 ± 0.3 | 21 ± 4 | > 60 | > 120 |
| Quercetin | 100 | 81 | 6.9 ± 1.0 | 16 ± 5 | > 60 | 7 ± 2 |
