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. 2022 Jun 22;12:10578. doi: 10.1038/s41598-022-14809-3

Table 3.

Associations between lifetime substance use and the five NDSS subdomains.

Lifetime use Smoking drive Nicotine tolerance Continuous smoking Behavioral priority Stereotypy
aOR (95% CI)1 p-value aOR (95% CI) p-value aOR (95% CI) p-value aOR (95% CI) p-value aOR (95% CI) p-value
Psilocybin 0.96 (0.90, 1.01) 0.170 0.96 (0.91, 1.02) 0.188 0.98 (0.92, 1.04) 0.475 0.93* (0.88, 0.99) 0.048 0.97 (0.91, 1.03) 0.335
Peyote 0.90 (0.81, 0.99) 0.061 0.89* (0.81, 0.98) 0.038 0.88* (0.80, 0.96) 0.022 0.91 (0.83, 1.00) 0.081 0.90 (0.82, 0.99) 0.058
Mescaline 0.82** (0.73, 0.92) 0.008 0.79** (0.72, 0.88) 0.002 0.84* (0.75, 0.93) 0.010 0.83** (0.74, 0.92) 0.008 0.86* (0.77, 0.95) 0.015
LSD 1.24*** (1.17, 1.32) 4.54e−05 1.21*** (1.14, 1.28) 1.61e−04 1.22*** (1.15, 1.29) 8.64e−05 1.21*** (1.14, 1.28) 1.09e−04 1.17*** (1.11, 1.24) 3.55e−04
MDMA/ecstasy 1.25*** (1.19, 1.32) 1.49e−05 1.32*** (1.25, 1.38) 1.57e−06 1.26*** (1.19, 1.33) 1.59e−05 1.23*** (1.17, 1.30) 1.90e−05 1.26*** (1.20, 1.31) 4.01e−06
PCP 1.01 (0.92, 1.12) 0.795 1.00 (0.91, 1.10) 0.954 1.01 (0.92, 1.11) 0.851 1.03 (0.94, 1.13) 0.521 1.03 (0.93, 1.13) 0.597
Cocaine 1.70*** (1.62, 1.79) 5.24e−09 1.68*** (1.60, 1.76) 3.50e−09 1.66*** (1.58, 1.74) 7.14e−09 1.67*** (1.60, 1.75) 3.61e−09 1.60*** (1.53, 1.68) 9.75e−09
Heroin 1.73*** (1.56, 1.93) 3.22e−06 1.70*** (1.54, 1.88) 2.72e−06 1.57*** (1.42, 1.73) 9.72e−06 1.51*** (1.36, 1.67) 2.38e−05 1.31*** (1.19, 1.44) 3.81e−04
Inhalants 1.03 (0.98, 1.10) 0.285 1.02 (0.96, 1.07) 0.599 1.00 (0.94, 1.06) 0.960 1.01 (0.96, 1.07) 0.643 0.96 (0.90, 1.02) 0.190
Pain Relievers 1.12*** (1.07, 1.16) 4.69e−04 1.11*** (1.07, 1.16) 7.16e−04 1.10** (1.06, 1.15) 0.002 1.09** (1.05, 1.14) 0.003 1.06* (1.02, 1.10) 0.024
Tranquilizers 1.17*** (1.12, 1.22) 5.98e−05 1.17*** (1.12, 1.21) 4.09e−05 1.14*** (1.09, 1.19) 2.58e−04 1.15*** (1.10, 1.21) 1.47e−04 1.10** (1.05, 1.15) 0.003
Stimulants 1.10*** (1.06, 1.14) 8.40e−04 1.11*** (1.07, 1.16) 5.11e−04 1.09** (1.05, 1.13) 0.002 1.10** (1.06, 1.14) 0.001 1.09** (1.05, 1.13) 0.002
Sedatives 1.00 (0.95, 1.05) 0.966 0.98 (0.94, 1.03) 0.427 0.98 (0.93, 1.02) 0.337 0.96 (0.92, 1.01) 0.163 0.93* (0.89, 0.97) 0.013
Marijuana 2.80*** (2.69, 2.91) 2.66e−12 2.80*** (2.69, 2.92) 2.45e−12 2.79*** (2.68, 2.90) 1.93e−12 2.78*** (2.66, 2.90) 3.53e−12 2.68*** (2.57, 2.79) 4.39e−12

Significant values conferring lowered odds of nicotine dependence are in bold.

1*p < 0.05; **p < 0.01; ***p < 0.001, aOR adjusted odds ratio, CI confidence interval.