. 2020 Nov 13;4:100018. doi: 10.1016/j.cpnec.2020.100018

Table 2.

Overview statistical analyses.

Analysis	Variables	Statistical model	Cohort/data set
1. Discovery DMPs	Outcome: DNA methylation levels (T₀, T₁, T₂)	Mixed model	PRISMO
1. Discovery DMPs	Predictor: PTSD score (T₀, T₁, T₂)	Mixed model	PRISMO
2. Identification DMRs and PRS as determinants	Outcome: PTSD score (T₀, T₁, T₂)	Mixed model	PRISMO
	Predictor:
	a. DMR methylation levels (T₀, T₁, T₂)
	b. PRS
3. Replication DMRs	Outcome: PTSD score (T₀, T₁, T₂)	Mixed model	MRS
3. Replication DMRs	Predictor: DMR methylation levels (T₀, T₁, T₂)	Mixed model	MRS
4. Correlations DMRs, PRS, and PTSD symptoms	a. DMR change score (T₀-T₁ or T₁-T₂) x PTSD score (T₀ to T₅)	Pearson’s correlation	PRISMO
	b. DMR change score x PRS
	c. PRS x PTSD score (T₀ to T₅)
5. Association DMRs and PRS with PTSD trajectories	Outcome: PTSD trajectory	Multinomial logistic regression	PRISMO (imputed)
	Predictor:
	a. DMR change score
	b. PRS
6. Prediction model delayed onset PTSD	Outcome: delayed PTSD trajectory (vs. resilient trajectory)	Stepwise backward logistic regression model	PRISMO (imputed)
6. Prediction model delayed onset PTSD	Predictors: DMR change score, variables in Table 1	Stepwise backward logistic regression model	PRISMO (imputed)

Note: DMP = differentially methylation position; PTSD = posttraumatic stress disorder; PRS = polygenic risk score.