Table 3.
List of differentially methylated regions (DMRs) that were significant determinants of longitudinal development of PTSD symptom score.
| Chromosomal position of DMR | Genes | Probes | P-value (Stouffer method) | P-value in determinant analysis | |
|---|---|---|---|---|---|
| DMR1 | chr22: 21368603, 21368765 |
TUBA3FP P2RX6 |
cg06912512 cg19789653 cg09481857 cg21014483 cg01038149 |
8.84 E−05 | 0.002 |
| DMR2 | chr22: 41487073, 41487283 | EP300 miR1281 | cg00500400 cg08131204 |
1.18 E−06 | 0.016 |
| DMR6 | chr8 82598501, 82598664 |
IMPA1 | cg05798523 cg23402311 cg03588978 cg04364718 cg12093930 |
1.87 E−06 | 0.033 |
| DMR7 | chr8: 144973617, 144973638 | - | cg26529963 cg03000485 |
9.19 E−05 | 0.040 |
Note: the column on determinant analysis provides the P-values for the analyses in which methylation levels were tested as determinants of longitudinal development of PTSD symptom scores; PTSD = posttraumatic stress disorder; DMR = differentially methylated region.