Fig. 7 |. CVD induces inflammatory bone marrow endothelial cell gene expression.
a, Experimental outline. WD, western diet. b–d, Differential gene expression in bone marrow endothelial cells assessed by RNA-seq (n = 3 mice per group). e–g, GSEA plots of gene sets related to inflammation. NES, normalized enrichment score; FDR, false discovery rate; GO, gene ontology; IFN-γ; interferon-γ; KEGG, Kyoto Encyclopedia of Genes and Genomes; LPS, lipopolysaccharide. h, Plot of gene set enrichment in Apoe−/− mice compared to controls. Neg., negative; posit., positive; reg., regulation; TLR, Toll-like receptor.