TABLE 2.
Changes in the DRSP score for individual symptoms from baseline to the endpoint
| Symptoms and distinct items | Q‐1 | I‐2 | Mean difference | 95% CI | P |
|---|---|---|---|---|---|
| 1. Depression | 6.8 | 5.2 | −1.6 | −3.15 to −0.16 | .031* |
| a. Felt depressed, sad, “down,” or “blue” | 2.5 | 1.9 | −0.6 | −1.08 to −0.05 | .036* |
| b. Felt hopeless | 2.0 | 1.4 | −0.6 | −0.97 to −0.23 | .001* |
| c. Felt worthless or guilty | 2.4 | 1.9 | −0.5 | −120 to 0.23 | .103 |
|
2. Anxiety Felt anxious, tense, “keyed up,” or “on edge” |
2.6 | 2.0 | −0.6 | −1.17 to −0.09 | .025* |
| 3. Mood swings | 5.4 | 4.1 | −1.3 | −2.50 to −0.11 | .013* |
| a. Had mood swings (eg, suddenly felt sad or tearful) | 2.7 | 2.0 | −0.7 | −1.40 to −0.09 | .017* |
| b. Was more sensitive to rejection or my feelings were easily hurt | 2.7 | 2.1 | −0.6 | −1.17 to 0.01 | .024* |
| 4. Irritability | 5.2 | 4.0 | −1.2 | −2.41 to −0.04 | .024* |
| a. Felt angry, irritable | 3.0 | 2.4 | −0.6 | −1.33 to 0.14 | .053 |
| b. Had conflicts or problems with people | 2.2 | 1.6 | −0.6 | −1.13 to −0.13 | .012* |
|
5. Decreased interest Had less interest in usual activities (eg, work, school, friends, and hobbies) |
2.2 | 1.7 | −0.5 | −0.93 to −0.04 | .014* |
|
6. Difficulty concentrating Had difficulty concentrating |
2.1 | 1.5 | −0.6 | −0.93 to −0.19 | .005* |
|
7. Fatigue or lack of energy Felt lethargic, tired, fatigued, or had a lack of energy |
2.9 | 2.4 | −0.5 | −1.04 to 0.11 | .087 |
| 8. Overeating or food cravings | 4.2 | 3.9 | −0.3 | −157 to 1.06 | .820 |
| a. Had increased appetite or overate | 2.1 | 2.1 | −0.0 | −0.68 to 0.68 | 1.000 |
| b. Had cravings for specific foods | 2.5 | 2.0 | 0.5 | −1.13 to 0.31 | .202 |
| 9. Insomnia or hypersomnia | 5.3 | 4.3 | −0.9 | −1.91 to 0.01 | .184 |
| a. Slept more, took naps, and found it hard to get up when intended | 2.8 | 2.3 | −0.5 | −0.90 to −0.02 | .078 |
| b. Had trouble getting to sleep or staying asleep | 2.5 | 2.0 | −0.5 | −1.12 to 0.16 | .202 |
| 10. Feeling overwhelmed | 4.4 | 3.1 | −1.3 | −2.45 to −0.16 | .017* |
| a. Felt overwhelmed or that I could not cope | 2.1 | 1.5 | −0.6 | −1.17 to −0.10 | .017* |
| b. Felt out of control | 2.3 | 1.7 | −0.7 | −1.31 to −0.03 | .038* |
| 11. Physical symptoms | 8.5 | 6.8 | −1.7 | −2.90 to −0.47 | .009* |
| a. Had breast tenderness | 2.0 | 1.7 | −0.3 | −0.75 to 0.09 | .107 |
| b. Had breast swelling, felt “bloated,” or had weight gain | 2.4 | 2.1 | −0.3 | −0.80 to 0.25 | .089 |
| c. Had headache | 2.1 | 1.6 | −0.5 | −0.91 to −0.14 | .012* |
| d. Had joint or muscle pain | 2.0 | 1.5 | −0.6 | −0.93 to −0.19 | .006* |
Abbreviations: CI, confidence interval; DRSP, Daily Record of Severity of Problems; I‐2, last intervention cycle; Q‐1, qualification cycle.
*P < .05.