Table 2.
Baseline patient characteristics prior to febrile neutropenic episodes
| Characteristics | Episodes in survivors n = 231 (%) | Episodes in non-survivors n = 33 (%) | p-value |
|---|---|---|---|
| Age ≥ 60 years | 26.41 | 24.24 | 0.791 |
| Female | 44.59 | 48.48 | 0.674 |
| Comorbidities | |||
| Hematologic disease | 89.61 | 84.85 | 0.381 |
| Essential hypertension | 11.26 | 21.21 | 0.153 |
| Dyslipidemia | 12.12 | 15.15 | 0.579 |
| Chronic kidney disease | 9.96 | 6.06 | 0.750 |
| Diabetes mellitus | 9.96 | 9.09 | 1.000 |
| HIV infection | 7.79 | 6.06 | 1.000 |
| Cardiovascular disease | 3.03 | 9.09 | 0.116 |
| Autoimmune diseases | 2.16 | 6.06 | 0.213 |
| Chronic obstructive pulmonary disease | 1.73 | 3.03 | 0.490 |
| Cirrhosis | 0.87 | 3.03 | 0.331 |
| Immunosuppressive drug use | 3.90 | 9.09 | 0.178 |
| Presence of bone marrow diseases/involvement | 48.05 | 48.48 | 0.963 |
| Cause of neutropenia | 0.271 | ||
| Chemotherapy-induced | 88.31 | 81.82 | |
| Due to bone marrow disease/involvement | 11.69 | 18.18 | |
| G-CSF | 0.137 | ||
| Not received | 12.12 | 21.21 | |
| Prophylaxis dose | 62.77 | 45.45 | |
| Treatment dose | 25.11 | 33.33 | |
| Presence of indwelling central venous catheter | 45.02 | 24.24 | 0.024* |
| Previous FN | 55.41 | 42.42 | 0.162 |
| Previous fungal infection | 13.42 | 12.12 | 1.000 |
| Previous antibiotics use 3 months prior to admission | 57.14 | 69.70 | 0.171 |
| Use of antibiotics 48 hours before FN onset | 6.93 | 18.18 | 0.041* |
Abbreviations: HIV = human immunodeficiency virus; G-CSF = granulocyte colony-stimulating factor; FN = febrile neutropenia.
⁎
p < 0.05