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. 2019 May 30;1:11–18. doi: 10.1016/j.iotech.2019.05.001

Figure 4.

Figure 4

Precise ultraviolet (UV) guidance by digital mirror devices. (A) CAGE-dye-stained tonsil tissue with geometric region of interest (ROI) before and after UV exposure. Scale bar 100 μm. (B) Circular ROIs (200-μm diameter) on cell pellet array and ‘glass’ and respective protein expression levels after digital spatial profiling (DSP) analysis. DSP counts are normalized to immunoglobulin G (IgG) controls to correct for noise. Scale bar 100 μm. (C) Geometric ROI on colorectal cancer tissue with internal segmentation for ‘tumor’ (red) and ‘stroma’ (green). Scale bar 100 μm. Heatmap of region-specific nCounter counts normalized to nuclei. (D) Circular ROI (200-μm diameter) with segmentation on ‘PanCK+ CD45- CD3-’ (blue), ‘PanCK- CD45+ CD3-’ (yellow) and ‘PanCK- CD45+ CD3+’ (red) cells and respective DSP counts after normalization to IgG controls. Scale bar 100 μm.