Table 1.
Gene expression Fold Up and Down-regulation (vs. 4 h Control group).
| Symbol | 4 h |
12 h |
|||||
|---|---|---|---|---|---|---|---|
| LPS | PA | LPS/PA | Ctl | LPS | PA | LPS/PA | |
| CCL2 | 2.09 | −1.25 | 1.07 | −3.67 | −1.41 | −2.83 | −1.25 |
| CCL22 | 1.90 | 1.62 | 1.51 | 2.51 | 1.87 | 2.37 | 3.17 |
| CCL24 | −1.78 | −1.85 | −1.02 | 2.76 | 2.05 | 2.61 | 2.41 |
| CCL3 | 1.37 | 1.39 | 1.21 | 2.72 | 2.02 | 2.57 | 2.95 |
| CCR1 | 1.43 | −1.26 | 1.90 | 2.49 | 1.85 | 2.59 | 2.17 |
| CCR2 | 1.87 | 2.22 | 2.21 | 2.36 | 2.16 | 1.80 | 22.82 |
| CXCL1 | 3.08 | −1.66 | 2.49 | −1.79 | 2.08 | −1.59 | 6.89 |
| CXCL10 | 2.06 | −1.66 | 1.63 | 1.27 | 1.09 | 1.20 | 3.88 |
| CXCL2 | 2.52 | −1.66 | 2.26 | −1.93 | 1.81 | 1.02 | 5.98 |
| IL15 | −1.05 | 1.42 | 1.46 | 3.57 | 2.20 | 3.74 | 3.42 |
| IL6 | 1.63 | 1.45 | 2.38 | −1.51 | −1.17 | 3.80 | 7.49 |
| CXCL8 | 1.89 | −2.00 | 1.82 | −2.73 | 1.17 | −1.48 | 4.42 |
| TNFSF14 | 0.55 | 1.08 | 1.37 | 4.21 | 3.13 | 3.98 | 3.68 |
| C3 | −1.72 | −1.87 | −2.37 | −2.25 | −1.92 | −1.48 | −2.58 |
| CCL2 | 2.09 | −1.25 | 1.07 | −3.67 | −1.41 | −2.83 | −1.25 |
| CCL11 | 1.18 | −1.24 | 1.02 | −1.79 | −1.19 | −3.46 | −2.32 |
| CCL5 | −1.55 | −1.50 | 1.09 | −4.18 | −4.76 | −4.42 | −4.79 |
| CD14 | −1.49 | −2.59 | −1.77 | −2.54 | −2.56 | −1.87 | −1.36 |
| CRP | −1.16 | −4.34 | −1.52 | −1.23 | −1.03 | 1.28 | 1.67 |
| CXCL6 | −1.18 | −2.26 | −2.21 | −1.11 | −1.74 | 1.02 | 2.45 |
| IL10RB | 1.09 | 1.14 | 1.09 | −2.06 | −3.58 | −3.01 | −4.39 |
| IL17A | −1.38 | −2.73 | −1.45 | −1.23 | −2.19 | −1.25 | 1.17 |
| TLR4 | −1.27 | 1.17 | 1.08 | −1.47 | −2.22 | −1.21 | 1.05 |
| TLR5 | −4.44 | −2.56 | −1.77 | −1.84 | −2.48 | −1.95 | −2.11 |
| TLR7 | −1.14 | 1.49 | 1.26 | −1.87 | −3.35 | −2.14 | −2.27 |
| GAPDH | −1.07 | −1.33 | −1.17 | −1.89 | −1.03 | −1.02 | −1.21 |
HMC3 were treated with 100 ng/ml of LPS, 200 μM of PA or LPS plus PA for 4 and 12 h. RNA was isolated and subjected to PCR array as described in the Methods. Bold numbers indicated fold changes (>2.0 or < -2.0) of gene expression compare with 4 h control group.