Table 3.
Frequency of drug resistance pattern according to treatment history for MDR-TB
| Band | Gene region or Mutation | New Cases (235) | Previously treated (24) | Unknown (20) | Frequency (Total) n=279 |
|---|---|---|---|---|---|
| rpoB | |||||
| WT1 | 506-509 | 0 | 0 | 0 | 0 |
| WT2 | 510-513 | 0 | 0 | 0 | 0 |
| WT3 | 513-517 | 1(0.43) | 1(4.17) | 1(5.00) | 3(1.08) |
| WT4 | 516-519 | 2(0.85) | 0 | 1(5.00) | 3(1.08) |
| WT5 | 518-522 | 1(0.43) | 0 | 0 | 1(0.36) |
| WT6 | 521-525 | 1(0.43) | 0 | 1(5.00) | 2(0.72) |
| WT7 | 526-529 | 9(3.83) | 2(8.33) | 0 | 11(3.94) |
| WT8 | 530-533 | 223(94.89) | 20(83.33) | 20(100) | 263(94.27) |
| MUT 1 | D516V | 0 | 0 | 1(5.00) | 1(0.36) |
| MUT 2 | H526Y | 4(1.70) | 1(4.17) | 0 | 5(1.79) |
| MUT 2B | H526D | 6(2.55) | 0 | 0 | 6(2.15) |
| MUT 3 | S531L | 223(94.89) | 22(91.67) | 19(95.00) | 264(94.62) |
| katG | |||||
| WT | 315 | 229(97.45) | 22(91.67) | 20(100) | 271(97.13) |
| MUT 1 | S315T1 | 230(97.87) | 21(87.50) | 20(100) | 271(97.13) |
| MUT 2 | S315T2 | 0 | 0 | 0 | 0 |
| inhA | |||||
| WT1 | −15/−16 | 5(2.13) | 1(4.17) | 1(5.00) | 7(2.51) |
| WT2 | −8 | 3(1.28) | 1(4.17) | 1(5.00) | 5(1.79) |
| MUT 1 | C15T | 5(2.13) | 1(4.17) | 0 | 6(2.15) |
| MUT 2 | A16G | 0 | 0 | 0 | 0 |
| MUT 3A | T8C | 0 | 1(4.17) | 0 | 1(0.36) |
| MUT 3B | T8A | 0 | 0 | 0 | 0 |