Table 4.
Frequency of drug resistance pattern from 2015-2019 in Pulmonary MDR-TB
| Band | Gene region or Mutation | 2015(52) | 2016(50) | 2017(56) | 2018(53) | 2019(68) | Total(279) |
|---|---|---|---|---|---|---|---|
| rpoB | |||||||
| WT1 | 506-509 | 0 | 0 | 0 | 0 | 0 | 0 |
| WT2 | 510-513 | 0 | 0 | 0 | 0 | 0 | 0 |
| WT3 | 513-517 | 0 | 2(4.00) | 0 | 0 | 1(1.47) | 3(1.08) |
| WT4 | 516-519 | 1(1.92) | 1(2.00) | 0 | 0 | 1(1.47) | 3(1.08) |
| WT5 | 518-522 | 1(1.92) | 0 | 0 | 0 | 0 | 1(0.36) |
| WT6 | 521-525 | 0 | 1(2.00) | 0 | 1(1.89) | 0 | 2(0.72) |
| WT7 | 526-529 | 4(7.69) | 3(6.00) | 0 | 2(3.77) | 2(2.94) | 11(3.94) |
| WT8 | 530-533 | 46(88.46) | 46(92.00) | 55(98.21) | 51(96.23) | 65(95.59) | 263(94.27) |
| MUT 1 | D516V | 0 | 1(2.00) | 0 | 0 | 0 | 1(0.36) |
| MUT 2A | H526Y | 3(5.77) | 2(4.00) | 0 | 0 | 0 | 5(1.79) |
| MUT 2B | H526D | 2(3.85) | 2(4.00) | 0 | 0 | 2(2.94) | 6(2.15) |
| MUT 3 | S531L | 46(88.46) | 44(88.00) | 56(100.00) | 53(100.00) | 65(95.59) | 264(94.62) |
| katG | |||||||
| WT | 315 | 49(94.23) | 48(96.00) | 55(98.21) | 52(98.11) | 67(98.53) | 271(97.13) |
| MUT 1 | S315T1 | 49(94.23) | 48(96.00) | 56(100.00) | 52(98.11) | 66(97.06) | 271(97.13) |
| MUT 2 | S315T2 | 0 | 0 | 0 | 0 | 0 | 0 |
| inhA | |||||||
| WT1 | −15/−16 | 2(3.85) | 3(6.00) | 0 | 1(1.89) | 1(1.47) | 7(2.51) |
| WT2 | −8 | 0 | 3(6.00) | 0 | 1(1.89) | 1(1.47) | 5(1.79) |
| MUT 1 | C15T | 2(3.85) | 2(4.00) | 0 | 1(1.89) | 1(1.47) | 6(2.15) |
| MUT 2 | A16G | 0 | 0 | 0 | 0 | 0 | 0 |
| MUT 3A | T8C | 0 | 0 | 0 | 0 | 1(1.47) | 1(0.36) |
| MUT 3B | T8A | 0 | 0 | 0 | 0 | 0 | 0 |