Figure 3.

Potential synergistic combinations with anti-CD47 treatment.

CD47–SIRPα pathway blockade in combination with therapies that increase the ‘eat me’ signals on tumor cells has the potential for synergistic clinical efficacy. Some types of chemotherapy and other cytotoxic agents increase the expression of ‘eat me’ signals on tumor cells. Similarly, tumor-targeted antibodies present Fc regions to the Fc receptors on phagocytes, triggering ADCP. Phagocytosis of tumor cells by macrophages or dendritic cells can lead to tumor cell antigen presentation to T cells, activating antitumor T-cell responses; therefore, combination of CD47–SIRPα pathway blockade with T-cell checkpoint inhibitors may also produce synergistic efficacy.

ADCP, antibody-dependent cellular phagocytosis; MHC, major histocompatibility complex; PD-1, programmed cell death protein 1; PD-L1, programmed death-ligand 1; SIRPα, signal-regulating protein alpha.