Table 1.

Statistics of variants obtained from analysis of exome sequencing samples from paired and orphan tumors following depletion of germline variants with the global population variation databases (gnomAD, dbSNP) and Asian/Indian (GenomeAsia, IndiGenomes, TMC-SNPdb 2.0) population germline variant databases, along with variants from the PON derived from 173 in-house normal exome samples

		Unique variants retained upon depletion with databases
	Unique variants	gnomAD + dbSNP	Indian/Asian ethnic-specific databases	Per tumor median % reduction by Indian/Asian databases post dbSNP + GnomAD depletion	Total variants depleted by Indian/Asian databases post dbSNP + GnomAD depletion
Paired Tumor-Normal Samples (n = 180)	360 352	119 608	117 029	2.27	2579
Orphan samples (n = 44)	378 995	88 089	86 729	3.18	1360