Figure 1.

Donor T cells mediating GVHD and/or GVT effect. Tumor-reactive donor T cells recognize antigens presented on tumor cells in the context of HLA. These antigens are derived either from mHA or tumor-specific antigens. While mHA can be substrates of a GVT effect mediated by mHA-restricted T cells, these T cells also recognize the same mHA on normal tissues, causing GVHD. Tumor regression without objective GVHD may be achieved by T cells recognizing antigens that are specific to a tumor (tumor-restricted T cells). mHA, minor histocompatibility antigen.