Table 3.
Changes in cartilage from baseline based on cartilage defect area and WORMS on MRI during 5-year follow-up.α
| Timepoint | Variables, mean ± SD (range) | P value† |
|---|---|---|
| Mean cartilage defect area, mm2 | ||
| Baseline | 282.6 ± 262.7 (29.4-826.4) | |
| 6 months | 274.8 ± 259.2 (28.2-824.3) | .575 |
| 2 years | 250.2 ± 268.4 (24.3-807.9) | .365 |
| 3 years | 245.3 ± 269.4 (14.8-804.0) | .102 |
| 4 years | 252.8 ± 286.9 (10.54-811.4) | .246 |
| 5 years | 251.1 ± 287.3 (8.48-817.32) | .248 |
| Mean WORMS cartilage sub-score of medial compartment, 0-30 points | ||
| Baseline | 16.6 ± 4.0 (12-23) | |
| 6 months | 16.2 ± 4.8 (9.5-24) | .223 |
| 2 years | 14.2 ± 6.2 (5-24) | .029 |
| 3 years | 13.9 ± 6.7 (3-24) | .031 |
| 4 years | 14.6 ± 7.4 (3-24) | .179 |
| 5 years | 15.2 ± 7.8 (3-25) | .341 |
| Total WORMS, 0-332 points | ||
| Baseline | 73.4 ± 27.8 (49.5-118) | |
| 6 months | 70.5 ± 26.8 (49-116) | .020 |
| 2 years | 65.5 ± 29.4 (32.5-120) | .016 |
| 3 years | 66.5 ± 30.7 (41-120) | .041 |
| 4 years | 73.0 ± 31.3 (41.5-124) | .799 |
| 5 years | 75.2 ± 31.9 (42.5-127) | .656 |
Values are presented as mean ± SD.
Statistical analyses were performed using the paired t- or Wilcoxon signed-rank tests.
Bold indicates statistical significance which was set at P < .05.
Abbreviations: MRI, magnetic resonance imaging; WORMS, whole-organ magnetic resonance imaging scores.