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. 2022 Jun 22;8(25):eabo5272. doi: 10.1126/sciadv.abo5272

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Fig. 7. — The model postulates that assembly starts with Munc18-1 bound to closed syntaxin-1 (A) (PDB code 3C98) and is initiated when the Munc18-1 loop unfurls to allow synaptobrevin binding (B) (model built manually). (C and D) Conformational changes in syntaxin-1 that are stimulated by Munc13-1 (not shown) lead to template complex configurations such as those of class1 and class2, where syntaxin-1 gradually opens and the syntaxin-1 linker nucleates interactions between the syntaxin-1 and synaptobrevin SNARE motifs. The color code is the same as in Fig. 1. (E) Binding to SNAP-25 (green) eventually leads to formation of the SNARE complex (PDB codes: H_abc domain 1BR0; SNARE four-helix bundle 1SFC). The N and C termini of the SNAREs are indicated in the relevant panels.